ABSTRACT
Objective: To systematically analyze the basic characteristics and contents of the current health standards for infectious disease, environmental health, school health and disinfection in the context of COVID-19 prevention and control, and provide support for the further optimization of epidemic prevention and control guidelines and reference for the revision and improvement of related health standards. Methods: Public health standards used in COVID-19 prevention and control were selected for a systematic comparison with "The Plan of COVID19 Prevention and Control (the 6(t)h Edition)" and other epidemic prevention and control guidelines from the perspectives of application scope and technical elements. Results: The current standards of public health are with scientificity, timeliness and feasibility. The application scope and technical elements of the current public health standards basically meet the needs of the prevention and control of COVID-19 epidemic, but the public health standardization system still needs improvement, and some public health standards need to be revised. Conclusions: The implementation of current public health standards can provide strong technical support for the prevention and control of COVID-19 epidemic. The experience obtained from COVID-19 epidemic prevention and control might promote the further improvement of the health standardization system.
Subject(s)
COVID-19 , Humans , Pandemics , Public Health , Reference Standards , SARS-CoV-2ABSTRACT
Objective: To explore the potential anti-coronavirus mechanism of Xiaoer Feire Kechuan Particles (XFKP). Methods: TCMIP database was used to search and summarize the information of each medicinal herbs-components-target of XFKP. All the candidate target genes were also searched. "Corona virus" was used as the key word in Genecards database to search for corona virus related targets, and the mapping of the active targets with XFKP were used to select the common targets as the research targets. The selected common targets will be found in the summarized database of each medicinal herbs-components-target. The common targets were imported into the STRING database to construct the network diagram of target interaction, and Cytoscape 3.3.0 software was used for visualization processing to screen out the core targets. With the help of OmicsBean analysis platform and String database, Gene ontology (GO) biological process analysis and KEGG signal pathway enrichment analysis were carried out on the target. Results: A total of 342 chemical components and 737 candidate target genes were obtained. Venny mapped 48 common targets, corresponding to 173 compounds, 19 core targets, and 27 main compounds. GO biological process (BP) entries included 3 420, cell component (CC) entries included 239, and molecular function (MF) entries included 343. Through KEGG enrichment analysis, 160 signal pathways related to the therapeutic effect of XFKP were obtained. The "medicinal herbs-components-target-pathway" network of the key targets of XFKP was established. Conclusion: The 173 compounds can intervene 160 signaling pathways by acting on 48 related targets, such as IL-17 signaling pathway, influenza A, etc., mainly involving anti-inflammation, immune regulation, relieving cough and asthma, antibacterial, antiviral and sedative aspects, providing theoretical basis for the treatment of corona virus-related diseases with XFKP.
ABSTRACT
Objective: To compare the technical elements of health standards for nosocomial infection control, health protection, health information, and health emergency and biosafety in the context of the prevention and control of COVID-19, and provide support for the further optimization of the epidemic prevention and control guidelines. Methods: Above mentioned health standards used in COVID-19 prevention and control were collected for a systematic comparison with "Guidelines for Prevention and Control of COVID-19 in Medical Institutions" (the 1(st) Edition) from the perspective of technical elements. Results: The application scope and technical elements of the current health standards basically meet the needs for the prevention and control of COVID-19 epidemic. Conclusions: The implementation of the current health standards can provide strong technical support for the prevention and control of COVID-19 epidemic. The experience obtained in the epidemic prevention and control can also contribute to the further revision and improvement of the health standards.